Fibroblast Growth Factor 23 (FGF23) and Disorders of Phosphate Metabolism
نویسندگان
چکیده
منابع مشابه
Fibroblast Growth Factor 23 (FGF23) and Disorders of Phosphate Metabolism
Derangements in serum phosphate level result in rickets/osteomalacia or ectopic calcification indicating that healthy people without these abnormalities maintain serum phosphate within certain ranges. These results indicate that there must be a regulatory mechanism of serum phosphate level. Fibroblast growth factor 23 (FGF23) was identified as the last member of FGF family. FGF23 is produced by...
متن کاملAblation of systemic phosphate-regulating gene fibroblast growth factor 23 (Fgf23) compromises the dentoalveolar complex.
Fibroblast growth factor-23 (FGF23) is a hormone that modulates circulating phosphate (P(i)) levels by controlling P(i) reabsorption from the kidneys. When FGF23 levels are deficient, as in tumoral calcinosis patients, hyperphosphatemia ensues. We show here in a murine model that Fgf23 ablation disrupted morphology and protein expression within the dentoalveolar complex. Ectopic matrix formatio...
متن کاملFibroblast growth factor 23 and its role in phosphate homeostasis.
Phosphate homeostasis is complex and incompletely understood. The identification of different factors involved in the regulation of phosphate balance, also called phosphatonins, has largely changed our view on the regulation of phosphate homeostasis. The active role of bone has been demonstrated clearly. Currently, maintaining phosphate homeostasis is considered the result of a complex network ...
متن کاملChronic Kidney Disease-Mineral Bone Disoder: Fibroblast Growth Factor-23 and Phosphate Metabolism
Chronic Kidney Disease (CKD) is a growing epidemic in the United States. There are hormonal changes that develop long before the mineral changes in patients with CKD occur. Increased Parathyroid Hormone (PTH) levels first become evident when the estimated Glomerular Filtration Rate (eGFR) is below 60 mL/min/1.73m 2 . High serum phosphate stimulates the secretion of the Fibroblast Growth Factor ...
متن کاملAssociations of fibroblast growth factor 23 with parameters of phosphate metabolism in incident peritoneal dialysis patients.
dialysis: a meta-analysis of randomized controlled trials. Perit Dial Int 2011; 31:179–88. 2. Paniagua R, Ventura MD, Avila–Díaz M, Cisneros A, Vicenté–Martínez M, Furlong MD, et al. Icodextrin improves metabolic and fluid management in high and high-average transport diabetic patients. Perit Dial Int 2009; 29:422–32. 3. Han SH, Ahn SV, Yun JY, Tranæus A, Han DS. Effects of icodextrin on patien...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Pediatric Endocrinology
سال: 2009
ISSN: 1687-9848,1687-9856
DOI: 10.1155/2009/496514